Medical information for doctors

Immunoadsorption in atopic eczema
by Prof. Dr. med. Kristian Reich

A new treatment option for patients with severe atopic eczema

Atopic syndromes include atopic eczema (also known as atopic dermatitis, eczema and neurodermatitis), allergic rhinoconjunctivitis and allergic asthma. All three conditions are believed today to be due to an underlying predisposition called atopic disposition.

Genetic factors are involved, including those concerning certain immune system reactions, and others concerning elements of the skin barrier. The latter include genetic variations in the filaggrin gene that encodes for a precursor protein of the corneal layer. Environmental factors play a role in the manifestation of these disorders.

Atopic eczema commonly starts several months after birth, manifesting in the form of itching, red and weeping eczema rashes in the face and on the body. The diaper area tends to be excluded. In children and adolescents, atopic eczema tends to be seen in the folds of the extremities. The skin symptoms may be less severe at this time and clear up altogether in some patients.